The Best Ergonomic Mice of 2025

Ergonomics mice come in a variety of shapes, sizes, and price tags. Whether you’re looking for a vertical layout, trackball design, or lightweight product, here are six of the best ergonomic mice currently on the market.

Finding the right ergonomic mouse isn’t an easy task. If you’re coming from a traditional mouse, you’ll need to navigate many unfamiliar terms, wild-looking designs, and put up with a few trade-offs. But the benefits of an ergonomic mouse far outweigh the cons if you’re experiencing wrist, hand, or arm pain—or spend prolonged hours in front of a computer screen.

Although you’ll stumble upon some variations, there are three popular types of ergonomic mice: vertical, trackball, and traditional. Vertical mice are designed to position your hand as if you were giving someone a handshake, relieving pressure on your arm and hand.

Trackball mice are typically built with a slightly inclined design, and they offer a trackball under your thumb to manipulate your on-screen cursor. The last group of ergonomic mice are built similar to a standard mouse but offer several customizable components or minor design tweaks to provide a comfortable user experience.

Determining which type of mouse is best for you comes down to preference. All three offer some relief compared to a standard design, but depending on your budget, workspace, and how you’ll use the mouse, one might be better suited for your lifestyle.

Trackball mice aren’t the best choice for gaming, for example, and vertical mice require some getting used to, which might be uncomfortable. Consider what you’ll be using the mouse for before you invest in an ergonomic mouse so you can be sure you’ll use what you purchase.

Once you’ve decided on an ergonomic mouse, you’ll have dozens of options to choose from. We’ve made your task a bit less daunting by putting together a list of our six favorite ergonomic mice. These mice are a great fit for every budget and offer a variety of vertical, trackball, and traditional designs.

The Logitech MX Master 3S, an upgraded version of the popular MX Master 3, is the best ergonomic mouse you can buy today. The brilliant design, incredible sensor, and high level of customization available all combine in a mouse that could change the way you work.

Ergonomic mice are designed to tilt your hand and wrist into a more natural position and reduce the need for hand movements. The relatively large body of this mouse does exactly that, with the extra buttons and scroll wheels cleverly positioned to help. Someone with small hands might struggle to use it efficiently, but it should be comfortable for the majority.

The two main “Quiet Click” buttons are on the top and are quieter than previous Logitech mice. The electromagnetic MagSpeed scroll wheel can be switched from smooth to rachet scroll using the button just behind it. On the side are two further programmable buttons and a thumb wheel.

The lack of movement in the two main buttons might feel strange if you are used to a definite click, as we discovered when we reviewed the mouse. However, if you’re alright with more muted mouse clicks, this won’t be an issue.

The mouse sensor is an upgrade over the Master MX 3 mouse. You can customize the DPI level from 200 to an incredible 8000, double that of its predecessor. This DPI range results in a very accurate and sensitive device that will work perfectly on almost any flat surface.

One of the only real downsides of this ergonomic mouse is that it isn’t available in a left-handed version. This is often the case with ergonomic mice, but a shame nonetheless. If you need a left-handed mouse, you might want to look into the Logitech Lift instead.

If you’re new to the world of vertical mice, it’ll take a few hours to acclimate to the new arm and finger posture. Stick with it, however, and your body will thank you—the vertical design is excellent at alleviating pain in your wrist, making them the perfect companion for long days behind the monitor.

As far as this niche mouse market is concerned, few products can go toe-to-toe with the MX Vertical Wireless Mouse from Logitech. Offering a 57-degree incline, wireless and wired connections, a rechargeable battery, and several customizable shortcut keys, there’s little you’ll be left wanting with the premium mouse.

In addition to the sleek ergonomics, Logitech included an impressive 4000 DPI sensor in the MX Vertical, which gives you added precision not often found in this type of mouse. Another high-end feature is the rechargeable battery, which can give you a full three hours of use after just a one-minute charge.

But all these features come at a price. The MX Vertical clocks in at $100, making it one of the most expensive vertical mice on the market. There’s no doubt you’re getting what you’re paying for, but the high price tag might put off anyone on the fence about using a vertical mouse.

If that’s the case, you’ll want to check out our favorite budget ergonomic mouse, which also happens to be of the vertical variety.

Much like the MX Vertical, the Anker AK-UBA offers a vertical ergonomic design that helps alleviate wrist and hand pain. Unlike Logitech’s premium device, however, Anker’s budget-friendly mouse clocks in at a budget-friendly $28—nearly $60 less than the competition.

Unsurprisingly, a few concessions were made to hit that price point. The most notable downgrade is the battery, which is no longer built-in and rechargeable and instead relies on two AAA batteries. It also uses a less robust sensor, maxing out at 1600 DPI (although it’s adjustable all the way down to 800).

Despite the lack of features, there’s still a lot to be excited about with Anker’s mouse. It still looks like a premium device, offers next and back buttons for easy web navigation, and it’ll even enter power-saving mode after going idle to help conserve its batteries.

All told, the AK-UBA offers much of the same functionality as a more expensive device while carrying a surprisingly low price tag. If you can look past a few shortcomings, the AK-UBA Wireless Vertical Mouse is a solid, reliable choice.

The Razer Basilisk V3 was built for comfortable gaming, especially if you’ve got medium to large hands. Its right-handed shape includes a thumb rest that keeps your grip natural during long sessions and stops your thumb from dragging across the desk. It’s a small thing, but it matters when you’re flicking fast or reaching for the side buttons in a heated match.

The thumb rest has a textured grip molded into the plastic, which means it avoids the rubbery stick-on panels you sometimes get with cheaper mice. It feels solid, gives decent control, and doesn’t collect fingerprints or grease. The matte finish on top adds to the grip without feeling rough, and the overall shape curves just enough to comfortably suit a palm.

Overall, the shape and layout are built to cut down on strain, which helps if you’re gaming into the early hours or even using it for work during the day. That said, it may feel a bit oversized if you’ve got smaller hands. Additionally, at 101 grams (3.5 oz), it’s heavier than the ultralight mice that twitchy FPS players chase after. For everyone else, though, the weight gives it a solid, premium feel.

But comfort isn’t the only thing you need from an ergonomic gaming mouse; you also need performance. Luckily, the Basilisk V3 delivers in this regard, too. There are 11 programmable buttons, which you can customize however you like via the Razer Synapse software, and its functionality is effectively doubled through Hypershift, a feature of Razer’s that lets you assign a second layer of functions to your mouse buttons. It’s a setup that works just as well for FPS players as it does for MMO macros or general multitasking.

Under the hood, you’re getting Razer’s Gen 2 Optical Switches, which means no debounce delay and no mechanical wear, just fast, crisp clicks that reliably hold up over time. The sensor is a 26,000 DPI Focus+ model, which offers more precision than most gamers will ever need. It tracks smoothly with zero jitter or lag, even when performing sharp turns or quick lifts. You can also tweak lift-off distance and DPI stages in the software if that’s your bag.

The scroll wheel is another standout feature of the Razer Basilisk V3. It allows you to toggle between traditional notched scrolling and a smooth, free-spin mode. Alternatively, the Smart-Reel feature can switch modes automatically based on how hard you flick. It also tilts left and right for extra input options. However, those who prefer that old-school clicky wheel feedback may well feel it to be a bit loose.

There’s no wireless option for this mouse, which might be a dealbreaker for some. But if you’re fine with a cord and want raw responsiveness and plenty of customization options, it’s hard to fault the V3’s performance.

While you’ll rarely find trackballs underneath your mouse nowadays, they’ve become popular options for ergonomic mice when placed under your thumb. Newcomers will need to go through an adjustment period, but if you suffer from wrist pain, this class of mice is a great option to explore.

Logitech once again finds itself on our list, as the ERGO M575 consistently ranks as one of the most popular and comfortable wireless trackball mice available. Sleek, minimal, and built entirely around an ergonomic fit, the ERGO M575 looks like a premium device—despite the gigantic trackball protruding from its side.

You can connect the trackball to your computer using either a USB receiver or Bluetooth, and it offers up to 24 months of battery life on a single AA battery. Logitech also made it easy to remove the trackball for periodic cleaning.

Best of all, the premium mouse costs just $50, making it affordable for anyone who wants to experience the ergonomic bliss of trackball mice.

The Glorious Model O Wireless doesn’t offer much in the way of traditional ergonomics—you won’t find a thumb rest, vertical orientation, or trackball—but its lightweight and ambidextrous design makes it a solid choice for users who don’t want to stray too far from their comfort zone.

As one of the lightest mice on the market (clocking in at just 69 grams), little effort is needed to glide the Model O across your desktop. Premium G-Skates constructed with 100% polytetrafluorethylene (PTFE) make it even easier to control the Model O. The skates are built with rounded edges, too, meaning you won’t have to worry about them snagging on loose fibers in your mousepad.

One of the best things about the Glorious Model O is the variety of models available. The Glorious Model O Wireless is the best fit for most people, although a Model O Minus Wireless is available if you need something a bit smaller.

If you don’t mind having a cable run across your desk, you can save a bit of cash by opting for the wired versions of the Model O or Model O Minus. These offer many of the same features but rely on a wired connection.