Li L, Soyhan I, Warszawik E, Van Rijn P. Layered double hydroxides: recent progress and promising perspectives toward biomedical applications. Sci: Adv; 2024. p. 2306035.
Du H, Zhang D, Peng F, Yeung KWK, Liu X. Two-dimensional layered double hydroxides for biomedical applications: from nano-systems to surface- and body-systems. Prog Mater Sci. 2024;142:101220.
Selvaraj S, Chauhan A, Verma R, Viswanathan K, Subbarayan R, Ghotekar S. Multifunctional biomedical applications of MXene-based hydrogels: A review. Inorg Chem Commun. 2024;164:112457.
Lee J, Seo HS, Park W, Park CG, Jeon Y, Park D-H. Biofunctional layered double hydroxide nanohybrids for Cancer therapy. Materials. 2022;15:7977.
Constantino VRL, Figueiredo MP, Magri VR, Eulálio D, Cunha VRR, Alcântara ACS, et al. Biomaterials based on organic polymers and layered double hydroxides nanocomposites: drug delivery and tissue engineering. Pharmaceutics. 2023;15:413.
Ameena Shirin VK, Sankar R, Johnson AP, Gangadharappa HV, Pramod K. Advanced drug delivery applications of layered double hydroxide. J Control Release. 2021;330:398–426.
Bian Y, Cai X, Lv Z, Xu Y, Wang H, Tan C et al. Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment. Adv, Sci, 2023;10:2301806.
Jing G, Yang L, Wang H, Niu J, Li Y, Wang S. Interference of layered double hydroxide nanoparticles with pathways for biomedical applications. Adv Drug Deliv Rev. 2022;188:114451.
Yu S, Choi G, Choy J-H. Multifunctional layered double hydroxides for drug delivery and imaging. Nanomaterials. 2023;13:1102.
Hu T, Gu Z, Williams GR, Strimaite M, Zha J, Zhou Z, et al. Layered double hydroxide-based nanomaterials for biomedical applications. Chem Soc Rev. 2022;51:6126–76.
Kankala RK. Nanoarchitectured two-dimensional layered double hydroxides-based nanocomposites for biomedical applications. Adv Drug Deliv Rev. 2022;186:114270.
Li C-S, Xu Y, Li J, Qin S-H, Huang S-W, Chen X-M, et al. Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration. BioMed Eng OnLine. 2025;24:13.
Pham DT, Thuy NTN, Thao NTP, Nhi LT, Thuy BTP. Naturally derived hydrogels for wound healing. Ther Deliv. 2025;16:349–63.
Holme S, Richardson SM, Bella J, Pinali C. Hydrogels for cardiac tissue regeneration: current and future developments. Int J Mol Sci. 2025;26:2309.
Ghahremani-Nasab M, Babaie S, Bazdar S, Paiva-Santos AC, Del Bakhshayesh MR, Akbari-Gharalari N, et al. Infertility treatment using polysaccharides-based hydrogels: new strategies in tissue engineering and regenerative medicine. J Nanobiotechnol. 2025;23:162.
Patel DK, Won S-Y, Jung E, Han SS. Recent progress in biopolymer-based electrospun nanofibers and their potential biomedical applications: A review. Int J Biol Macromol. 2025;293:139426.
Selvaraj S, Dutta V, Gopalakrishnan C, Subbarayan R, Rana G, Radhakrishnan A, et al. Biomedical potential of hydrogels: a multifaceted approach to innovative medication delivery. Emergent Mater. 2024;7:721–63.
Romaniuk P, Kołodziejska B, Kolmas J. Silicocarnotite-A new ceramic material with potential application in bone tissue regeneration. J Biomed Mater Res A. 2025;113:e37902.
Gani MA, Marhaeny HD, Lee G, Rahmawati SF, Anjalikha PDA, Sugito T et al. Ceramic-based 3D printed bone graft in bone tissue reconstruction: a systematic review and proportional meta-analysis of clinical studies. Expert Rev Med Devices 2025.
Pan Y, Zhao H, Huang W, Liu S, Qi Y, Huang Y. Metal-Protein hybrid materials: unlocking new frontiers in biomedical applications. Adv Healthc Mater. 2025;14:e2404405.
Y W, Y ZLRY. C, D W, W Z, et al. Metal-phenolic network biointerface-mediated cell regulation for bone tissue regeneration. Volume 30. Bio: Mater Today; 2024.
He X, Zhu Y, Ma B, Xu X, Huang R, Cheng L et al. Bioactive 2D nanomaterials for neural repair and regeneration. Adv, Drug Deliv, Rev, 2022;187:114379.
Li X, Wang Y, Guo L, Geng X, Wang H, Dong A, et al. Long duration sodium hyaluronate hydrogel with dual functions of both growth prompting and acid-triggered antibacterial activity for bacteria-infected wound healing. Int J Biol Macromol. 2024;274:133423.
Zhang F, He X, Dong K, Yang L, Ma B, Liu Y, et al. Combination therapy with ultrasound and 2D nanomaterials promotes recovery after spinal cord injury via Piezo1 downregulation. J Nanobiotechnol. 2023;21:91.
Wang Z, Yang H, Xu X, Hu H, Bai Y, Hai J, et al. Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway. Bioact Mater. 2023;22:75–90.
Qian Y, Yang H, Bai Y, Hu H, Yang L, Mei G, et al. Bioactive layered double hydroxide nanoparticles loaded calcein under GelMA scaffolds promoted osteogenesis and angiogenesis for bone regeneration. Mater Des. 2024;238:112621.
Wang G, Lv Z, Wang T, Hu T, Bian Y, Yang Y, et al. Surface functionalization of hydroxyapatite scaffolds with MgAlEu-LDH nanosheets for High-Performance bone regeneration. Adv Sci (Weinh Baden-Wurtt Ger). 2022;10:e2204234.
Qian J, Zhang Y, Chen Z, Du Y, Ni B-J. NiCo layered double hydroxides/nife layered double hydroxides composite (NiCo-LDH/NiFe-LDH) towards efficient oxygen evolution in different water matrices. Chemosphere. 2023;345:140472.
Hobbs C, Downing C, Jaskaniec S, Nicolosi V. TEM and EELS characterization of Ni–Fe layered double hydroxide decompositions caused by electron beam irradiation. Npj 2D Mater Appl. 2021;5:1–9.
Musella E, Gualandi I, Ferrari G, Mastroianni D, Scavetta E, Giorgetti M, et al. Electrosynthesis of Ni/Al layered double hydroxide and reduced graphene oxide composites for the development of hybrid capacitors. Electrochim Acta. 2021;365:137294.
Mallakpour S, Hatami M, Hussain CM. Recent innovations in functionalized layered double hydroxides: fabrication, characterization, and industrial applications. Adv Colloid Interface Sci. 2020;283:102216.
Tonelli D, Gualandi I, Musella E, Scavetta E. Synthesis and characterization of layered double hydroxides as materials for electrocatalytic applications. Nanomater (Basel Switz). 2021;11:725.
Jiang Y, Shen Z, Tang C-S, Shi B. Synthesis and application of waste-based layered double hydroxide: A review. Sci Total Environ. 2023;903:166245.
Knorpp J, Zawisza A, Huangfu A, Borzì S, Clark AH, Kata A. Hydrothermal synthesis of multi-cationic high-entropy layered double hydroxides. RSC Adv. 2022;12:26362–71.
Farhan A, Khalid A, Maqsood N, Iftekhar S, Sharif HMA, Qi F, et al. Progress in layered double hydroxides (LDHs): synthesis and application in adsorption, catalysis and photoreduction. Sci Total Environ. 2024;912:169160.
Fu Y, Fu X, Song W, Li Y, Li X, Yan L. Recent progress of layered double Hydroxide-Based materials in wastewater treatment. Mater (Basel Switz). 2023;16:5723.
Yasaei M, Khakbiz M, Ghasemi E, Zamanian A. Synthesis and characterization of ZnAl-NO3(-CO3) layered double hydroxide: A novel structure for intercalation and release of Simvastatin. Appl Surf Sci. 2019;467–468:782–91.
Gabriel R, Dos Santos Lins PV, Vilela F, de AM SHV, Brandão RJ, Soletti JI, et al. Synthesis of layered double hydroxides: investigating the impact of stirring conditions and reactor design parameters. Heliyon. 2024;10:e30116.
Lin T, Wang H, Song Z, Huang M, An S, Chen W et al. Insight into the simultaneous Super-Stable mineralization of AsO4 3-, Cd2 + and Pb2 + Using MgFe-LDHs. Chem (Weinh Bergstr Ger) 2024:e202403877.
Padalkar NS, Sadavar SV, Shinde RB, Patil AS, Patil UM, Dhawale DS, et al. Layer-by-layer nanohybrids of Ni-Cr-LDH intercalated with 0D polyoxotungstate for highly efficient hybrid supercapacitor. J Colloid Interface Sci. 2022;616:548–59.
Kim Y, Son Y, Bae S, Kim T-H, Hwang Y. Adsorption of chromate ions by layered double Hydroxide-Bentonite nanocomposite for groundwater remediation. Nanomater (Basel Switz). 2022;12:1384.
An S, Shang N, Chen B, Kang Y, Su M, Wang C, et al. Co-Ni layered double hydroxides wrapped on leaf-shaped copper oxide hybrids for non-enzymatic detection of glucose. J Colloid Interface Sci. 2021;592:205–14.
Amin KM, Muench F, Kunz U, Ensinger W. 3D NiCo-Layered double hydroxide@ni nanotube networks as integrated free-standing electrodes for nonenzymatic glucose sensing. J Colloid Interface Sci. 2021;591:384–95.
Lu X, Xue H, Gong H, Bai M, Tang D, Ma R, et al. 2D layered double hydroxide nanosheets and their derivatives toward efficient oxygen evolution reaction. Nano-Micro Lett. 2020;12:86.
Zhang Y, Xu H, Lu S. Preparation and application of layered double hydroxide nanosheets. RSC Adv. 2021;11:24254–81.
Izbudak B, Cecen B, Anaya I, Miri AK, Bal-Ozturk A, Karaoz E. Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications. RSC Adv. 2021;11:30237–52.
Su Z, Boucetta H, Shao J, Huang J, Wang R, Shen A, et al. Next-generation aluminum adjuvants: Immunomodulatory layered double hydroxide NanoAlum reengineered from first-line drugs. Acta Pharm Sin B. 2024;14:4665–82.
Oxford Pharmascience Ltd. An Open-label, Single-dose, randomised, crossover study to evaluate changes in the pharmacokinetics of ibuprofen from ibuprofen-LDH dosed with and without release modifying excipients in normal, healthy, adult subjects. clinicaltrials.gov; 2017.
Lin C-W, Lin S-X, Kankala RK, Busa P, Deng J-P, Lue S-I, et al. Surface-functionalized layered double hydroxide nanocontainers as bile acid sequestrants for Lowering hyperlipidemia. Int J Pharm. 2020;590:119921.
Li M, Li L, Lin S. Efficient antimicrobial properties of layered double hydroxide assembled with transition metals via a facile Preparation method. Chin Chem Lett. 2020;31:1511–5.
Zhang D, Li M, Xu R, Xie J, Zhang Y, Qian S, et al. Complementary and synergistic design of Bi-Layered double hydroxides modified magnesium alloy toward multifunctional orthopedic implants. Adv Healthc Mater. 2023;12:2201367.
Murali A, Lokhande G, Deo KA, Brokesh A, Gaharwar AK. Emerging 2D nanomaterials for biomedical applications. Mater Today. 2021;50:276–302.
Mahgoub SM, Essam D, Eldin ZE, Moaty SAA, Shehata MR, Farghali A, et al. Carbon supported ternary layered double hydroxide nanocomposite for Fluoxetine removal and subsequent utilization of spent adsorbent as antidepressant. Sci Rep. 2024;14:3990.
Cao Z, Liu J, Yang X. Deformable nanocarriers for enhanced drug delivery and cancer therapy. Explor (Beijing China). 2024;4:20230037.
Fu H, Chen Z, Chen X, Jing F, Yu H, Chen D, et al. Modification strategies for development of 2D Material-Based electrocatalysts for alcohol oxidation reaction. Adv Sci (Weinh Baden-Wurtt Ger). 2024;11:e2306132.
Khalili L, Dehghan G, Fazli A, Khataee A. State-of-the-art advancement of surface functionalized layered double hydroxides for cell-specific targeting of therapeutics. Adv Colloid Interface Sci. 2023;314:102869.
Ge Y-W, Fan Z-H, Ke Q-F, Guo Y-P, Zhang C-Q, Jia W-T. SrFe12O19-doped nano-layered double hydroxide/chitosan layered scaffolds with a nacre-mimetic architecture guide in situ bone ingrowth and regulate bone homeostasis. Mater Today Bio. 2022;16:100362.
Cheng S, Zhang D, Li M, Liu X, Zhang Y, Qian S, et al. Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg. Bioact Mater. 2021;6:91–105.
Peng F, Wang D, Zhang D, Cao H, Liu X. The prospect of layered double hydroxide as bone implants: A study of mechanical properties, cytocompatibility and antibacterial activity. Appl Clay Sci. 2018;165:179–87.
Figueiredo MP, Borrego-Sánchez A, García-Villén F, Miele D, Rossi S, Sandri G, et al. Polymer/Iron-Based layered double hydroxides as multifunctional wound dressings. Pharmaceutics. 2020;12:1130.
Moaty SAA, Farghali AA, Khaled R. Preparation, characterization and antimicrobial applications of Zn-Fe LDH against MRSA. Mater Sci Eng: C. 2016;68:184–93.
Costa MI, Sarmento-Ribeiro AB, Gonçalves AC. Zinc: from biological functions to therapeutic potential. Int J Mol Sci. 2023;24:4822.
Fu H, Wang L, Bao Q, Ni D, Hu P, Shi J. Acid neutralization and immune regulation by Calcium-Aluminum-Layered double hydroxide for osteoporosis reversion. J Am Chem Soc. 2022;144:8987–99.
Gicha BB, Tufa LT, Kang S, Goddati M, Bekele ET, Lee J. Transition Metal-Based 2D layered double hydroxide nanosheets: design strategies and applications in oxygen evolution reaction. Nanomater (Basel Switz). 2021;11:1388.
Zhu Z, Lin Y, Li L, Liu K, Wen W, Ding S, et al. 3D printing Drug-Free scaffold with Triple-Effect combination induced by Copper-Doped layered double hydroxides for the treatment of bone defects. ACS Appl Mater Interfaces. 2023;15:58196–211.
Dai Q, Li Q, Gao H, Yao L, Lin Z, Li D, et al. 3D printing of Cu-doped bioactive glass composite scaffolds promotes bone regeneration through activating the HIF-1α and TNF-α pathway of hUVECs. Biomater Sci. 2021;9:5519–32.
Peng C, Yu Z, Wu W, Li J, Wang E. CuFe layered double hydroxide as Self-Cascade nanoreactor for efficient antibacterial therapy. ACS Appl Mater Interfaces. 2023;15:56678–88.
Zhang W, Zhao Y, Wang W, Peng J, Li Y, Shangguan Y, et al. Colloidal surface engineering: growth of layered double hydroxides with intrinsic Oxidase-Mimicking activities to fight against bacterial infection in wound healing. Adv Healthc Mater. 2020;9:2000092.
Zhang D, Cheng S, Tan J, Xie J, Zhang Y, Chen S, et al. Black Mn-containing layered double hydroxide coated magnesium alloy for osteosarcoma therapy, bacteria killing, and bone regeneration. Bioact Mater. 2022;17:394–405.
Chu M, Sun Z, Fan Z, Yu D, Mao Y, Guo Y. Bi-directional regulation functions of lanthanum-substituted layered double hydroxide nanohybrid scaffolds via activating osteogenesis and inhibiting osteoclastogenesis for osteoporotic bone regeneration. Theranostics. 2021;11:6717–34.
Cao D, Xu Z, Chen Y, Ke Q, Zhang C, Guo Y. Ag-loaded MgSrFe-layered double hydroxide/chitosan composite scaffold with enhanced osteogenic and antibacterial property for bone engineering tissue. J Biomed Mater Res B: Appl Biomater. 2018;106:863–73.
Liao C, He D, Yin K, Lin Y, Chen Y, Zhang Z, et al. Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats. J Mater Chem B. 2024;12:1592–603.
Pang D, Zhang Z, Zhou Y, Fu Z, Li Q, Zhang Y, et al. The process and mechanism for cesium and rubidium extraction with saponified 4-tert-butyl-2-(α-methylbenzyl) phenol. Chin J Chem Eng. 2022;46:31–9.
An Z, Sun J, Mei Q, Wei B, Li M, Xie J, et al. Unravelling the effects of complexation of transition metal ions on the hydroxylation of catechol over the whole pH region. J Environ Sci. 2022;115:392–402.
Yao M, Hao X, Shao H, Wang D, Li B, Xing S, et al. Metallic Nanoparticle-Doped oxide semiconductor film for bone tumor suppression and bone regeneration. ACS Appl Mater Interfaces. 2022;14:47369–84.
Ferreira Meneses CC, Monteiro de Sousa PR, Pinto LC, Coelho GM, Ferreira da Silva T, Ferreira LO, et al. Layered double hydroxide–indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases. J Drug Deliv Sci Technol. 2021;61:102190.
Wang Y, Mei X, Bian Y, Hu T, Weng X, Liang R, et al. Magnesium-based layered double hydroxide nanosheets: a new bone repair material with unprecedented osteogenic differentiation performance. Nanoscale. 2020;12:19075–82.
Wei Su L, Lin DJ, Yen Uan J. Novel dental resin composites containing LiAl-F layered double hydroxide (LDH) filler: fluoride release/recharge, mechanical properties, color change, and cytotoxicity. Dent Mater. 2019;35:663–72.
Bini M, Ambrogi V, Donnadio A, Di Michele A, Ricci P, Nocchetti M. Layered double hydroxides intercalated with fluoride and methacrylate anions as multifunctional filler of acrylic resins for dental composites. Appl Clay Sci. 2020;197:105796.
Bernardo MP, Ribeiro C. Zn–Al-based layered double hydroxides (LDH) active structures for dental restorative materials. J Mater Res Technol. 2019;8:1250–7.
de Sousa ALMD, Dos Santos WM, de Souza ML, Silva LCPBB, Yun AEHK, Aguilera CSB, et al. Layered double hydroxides as promising excipients for drug delivery purposes. Eur J Pharm Sci: Off J Eur Fed Pharm Sci. 2021;165:105922.
Cao Y, Zheng D, Zhang F, Pan J, Lin C. Layered double hydroxide (LDH) for multi-functionalized corrosion protection of metals: A review. J Mater Sci Technol. 2022;102:232–63.
Zhang L-X, Hu J, Jia Y-B, Liu R-T, Cai T, Xu ZP. Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction. Nanoscale. 2021;13:7533–49.
Wang Y, Zhou L, Fang L, Cao F. Multifunctional carboxymethyl Chitosan derivatives-layered double hydroxide hybrid nanocomposites for efficient drug delivery to the posterior segment of the eye. Acta Biomater. 2020;104:104–14.
Xu Y, Kong Y, Xu J, Li X, Gou J, Yin T, et al. Doxorubicin intercalated copper diethyldithiocarbamate functionalized layered double hydroxide hybrid nanoparticles for targeted therapy of hepatocellular carcinoma. Biomater Sci. 2020;8:897–911.
Peng L, Mei X, He J, Xu J, Zhang W, Liang R, et al. Monolayer nanosheets with an extremely high drug loading toward controlled delivery and Cancer theranostics. Adv Mater. 2018;30:1707389.
Zhang H, Zhang L, Cao Z, Cheong S, Boyer C, Wang Z, et al. Two-Dimensional Ultra-Thin nanosheets with extraordinarily high drug loading and long blood circulation for Cancer therapy. Small (Weinh Bergstr Ger). 2022;18:e2200299.
Adampourezare M, Nikzad B. Layered double hydroxide nanoparticles as signal-amplification elements in DNA biosensors: recent progress and challenges. Microchem J. 2024;199:110151.
Wang C, Long Y, Deng Y, Han Y, Tishkevich D, Ha MN, et al. Hexagonal Boron nitride nanomaterials for biomedical applications. BMEMat. 2024;2:e12068.
Yu X, Xu C, Sun J, Xu H, Huang H, Gan Z, et al. Recent developments in two-dimensional molybdenum disulfide-based multimodal cancer theranostics. J Nanobiotechnol. 2024;22:515.
Wang Z, Cheng H, Sheng Y, Chen Z, Zhu X, Ren J, et al. Biofunctionalized graphene oxide nanosheet for amplifying antitumor therapy: multimodal high drug encapsulation, prolonged hyperthermal window, and deep-site burst drug release. Biomaterials. 2022;287:121629.
Chen L, Qian M, Jiang H, Zhou Y, Du Y, Yang Y, et al. Multifunctional mesoporous black phosphorus-based nanosheet for enhanced tumor-targeted combined therapy with biodegradation-mediated metastasis Inhibition. Biomaterials. 2020;236:119770.
Sridhar V, Podjaski F, Alapan Y, Kröger J, Grunenberg L, Kishore V et al. Biocompatible carbon nitride-based light-driven microswimmer propulsion in biological and ionic media with responsive on-demand drug delivery 2021.
Wang Y, Zhang X, Yue H. Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment. J Nanobiotechnol. 2024;22:67.
He L, Sarkar S, Barras A, Boukherroub R, Szunerits S, Mandler D. Electrochemically stimulated drug release from flexible electrodes coated electrophoretically with doxorubicin loaded reduced graphene oxide. Chem Commun. 2017;53:4022–5.
Althumayri K, Guesmi A, Abd El-Fattah W, Khezami L, Soltani T, Hamadi NB, et al. Effective adsorption and removal of doxorubicin from aqueous solutions using mesostructured silica nanospheres: Box-Behnken design optimization and adsorption performance evaluation. ACS Omega. 2023;8:14144–59.
Sahoo DP, Das KK, Mansingh S, Sultana S, Parida K. Recent progress in first row transition metal layered double hydroxide (LDH) based electrocatalysts towards water splitting: A review with insights on synthesis. Coord Chem Rev. 2022;469:214666.
Mallakpour S, Azadi E, Hussain CM. Recent advancements in synthesis and drug delivery utilization of polysaccharides-based nanocomposites: the important role of nanoparticles and layered double hydroxides. Int J Biol Macromol. 2021;193:183–204.
Roy AS, de Beer M, Pillai SK, Ray SS. Application of layered double hydroxides as a Slow-Release phosphate source: A comparison of hydroponic and soil systems. ACS Omega. 2023;8:15017–30.
Kang HR, Da Costa Fernandes CJ, Da Silva RA, Constantino VRL, Koh IHJ, Zambuzzi WF. Mg–Al and Zn–Al layered double hydroxides promote dynamic expression of marker genes in osteogenic differentiation by modulating Mitogen-Activated protein kinases. Adv Healthc Mater. 2018;7:1700693.
Zhai P, Peng X, Li B, Liu Y, Sun H, Li X. The application of hyaluronic acid in bone regeneration. Int J Biol Macromol. 2020;151:1224–39.
Wang Y, Shen S, Hu T, Williams GR, Bian Y, Feng B, et al. Layered double hydroxide modified bone cement promoting osseointegration via multiple osteogenic signal pathways. ACS Nano. 2021;15:9732–45.
Fathi-karkan S, Shamsabadipour A, Moradi A, Rahdar A, Pourmadadi M, Romanholo Ferreira LF. Four-Dimensional Print Techniques: Compr Rev Biomedical Tissue Eng Developments BioNanoScience. 2024;14:4189–218.
Lv Z, Hu T, Bian Y, Wang G, Wu Z, Li H, et al. A MgFe-LDH Nanosheet‐Incorporated smart Thermo‐Responsive hydrogel with controllable growth factor releasing capability for bone regeneration. Adv Mater. 2023;35:2206545.
Ahmadi S, Shafiei SS, Sabouni F. Electrospun nanofibrous scaffolds of Polycaprolactone/Gelatin reinforced with layered double hydroxide nanoclay for nerve tissue engineering applications. ACS Omega. 2022;7:28351–60.
He X, Zhu Y, Yang L, Wang Z, Wang Z, Feng J, et al. MgFe-LDH nanoparticles: A promising leukemia inhibitory factor replacement for Self-Renewal and pluripotency maintenance in cultured mouse embryonic stem cells. Adv Sci. 2021;8:2003535.
He W, MacRenaris KW, Griebel A, Kwesiga MP, Freitas E, Gillette A, et al. Semi-quantitative elemental imaging of corrosion products from bioabsorbable Mg vascular implants in vivo. Bioact Mater. 2025;43:225–39.
Bessa-Gonçalves M, Ribeiro-Machado C, Costa M, Ribeiro CC, Barbosa JN, Barbosa MA, et al. Magnesium incorporation in fibrinogen scaffolds promotes macrophage polarization towards M2 phenotype. Acta Biomater. 2023;155:667–83.
Fu H, Guo Y, Fang W, Wang J, Hu P, Shi J. Anti-Acidification and immune regulation by Nano-Ceria-Loaded Mg-Al layered double hydroxide for rheumatoid arthritis therapy. Adv Sci (Weinh Baden-Wurtt Ger). 2024;11:e2307094.
Zheng X, Chen L, Tan J, Miao J, Liu X, Yang T, et al. Effect of micro/nano-sheet array structures on the osteo-immunomodulation of macrophages. Regen Biomater. 2022;9:rbac075.
Raina DB, Matuszewski L-M, Vater C, Bolte J, Isaksson H, Lidgren L, et al. A facile one-stage treatment of critical bone defects using a calcium sulfate/hydroxyapatite biomaterial providing Spatiotemporal delivery of bone morphogenic protein–2 and Zoledronic acid. Sci Adv. 2020;6:eabc1779.
Kang H, Kim M, Feng Q, Lin S, Wei K, Li R, et al. Nanolayered hybrid mediates synergistic co-delivery of ligand and ligation activator for inducing stem cell differentiation and tissue healing. Biomaterials. 2017;149:12–28.
Costard LS, Kelly DC, Power RN, Hobbs C, Jaskaniec S, Nicolosi V, et al. Layered double hydroxide as a potent Non-viral vector for nucleic acid delivery using Gene-Activated scaffolds for tissue regeneration applications. Pharmaceutics. 2020;12:1219.
Yang L, He X, Jing G, Wang H, Niu J, Qian Y, et al. Layered double hydroxide nanoparticles with osteogenic effects as MiRNA carriers to synergistically promote osteogenesis of MSCs. ACS Appl Mater Interfaces. 2021;13:48386–402.
Zhang J, Zuo H, Fu Y, Cao Y, Li Q, Zhang Q, et al. Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures. J Nanobiotechnol. 2024;22:144.
Piao H, Kim MH, Cui M, Choi G, Choy J-H. Alendronate-Anionic clay nanohybrid for enhanced osteogenic proliferation and differentiation. J Korean Med Sci 2019;34.
Shokrolahi F, Latif F, Shokrollahi P, Farahmandghavi F, Shokrollahi S. Engineering Atorvastatin loaded Mg-Mn/LDH nanoparticles and their composite with PLGA for bone tissue applications. Int J Pharm. 2021;606:120901.
Bernardo MP, Rodrigues BCS, De Oliveira TD, Guedes APM, Batista AA, Mattoso LHC. Naproxen/Layered double hydroxide composites for Tissue-Engineering applications: physicochemical characterization and biological evaluation. Clays Clay Min. 2020;68:623–31.
Sayyar Z, Sadigh MK, Pakdel PM. Nanoarchitectonics of a novel drug delivery system using Nickel–Iron double layer hydroxide in β-Cyclodextrin/Chitosan for controlled release of Sunitinib malate. J Inorg Organomet Polym Mater 2025:1–14.
Chen Y, Qiu X, Li C, Zhang Y, Li Y. Red fluorescence of Eu3+-Doped ZnAl-LDH response to intercalation and release of ibuprofen. J Fluoresc. 2022;32:533–47.
Sekar Jeyakumar GF, Gunasekaran D, Panneerselvam Manimegalai N, Tiruchirapalli Sivagnanam U. Tailored thymoquinone intercalated layered double hydroxide (LDH) nanocomposites to accelerate mineralization for enhanced osteogenesis. Appl Clay Sci. 2024;252:107339.
Chen Y-X, Zhu R, Ke Q-F, Gao Y-S, Zhang C-Q, Guo Y-P. MgAl layered double hydroxide/chitosan porous scaffolds loaded with PFTα to promote bone regeneration. Nanoscale. 2017;9:6765–76.
Chen Y-X, Zhu R, Xu Z, Ke Q-F, Zhang C-Q, Guo Y-P. Self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system for bone repair materials. J Mater Chem B. 2017;5:2245–53.
Wang Z, Yang H, Bai Y, Cheng L, Zhu R. rBMSC osteogenic differentiation enhanced by graphene quantum Dots loaded with Immunomodulatory layered double hydroxide nanoparticles. Biomed Mater. 2022;17:024101.
Belgheisi G, Haghbin Nazarpak M, Solati-Hashjin M. Fabrication and evaluation of combined 3D printed/pamidronate-layered double hydroxides enriched electrospun scaffolds for bone tissue engineering applications. Appl Clay Sci. 2022;225:106538.
Bian Y, Hu T, Zhao K, Cai X, Li M, Tan C, et al. A LDH-Derived metal sulfide Nanosheet-Functionalized bioactive glass scaffold for vascularized osteogenesis and periprosthetic infection prevention/treatment. Adv Sci (Weinh Baden-Wurtt Ger). 2024;11:e2403009.
Tang Y-Q, Wang Q-Y, Ke Q-F, Zhang C-Q, Guan J-J, Guo Y-P. Mineralization of ytterbium-doped hydroxyapatite Nanorod arrays in magnetic Chitosan scaffolds improves osteogenic and angiogenic abilities for bone defect healing. Chem Eng J. 2020;387:124166.
Bian Y, Zhao K, Hu T, Tan C, Liang R, Weng X. A se Nanoparticle/MgFe-LDH composite nanosheet as a multifunctional platform for osteosarcoma eradication, antibacterial and bone reconstruction. Adv Sci (Weinh Baden-Wurtt Ger) 2024:e2403791.
Eskandari N, Shafiei SS. Fabrication and evaluation of layered double Hydroxide-Enriched ß-Tricalcium phosphate nanocomposite granules for bone regeneration: in vitro study. Mol Biotechnol. 2021;63:477–90.
Eskandari N, Shafiei SS, Dehghan MM, Farzad-Mohajeri S. In vivo evaluation of bone regeneration behavior of novel Β ‐tricalcium phosphate/layered double hydroxide nanocomposite granule as bone graft substitutes. J Biomed Mater Res B: Appl Biomater. 2022;110:1001–11.
Shi J-J, Ge Y-W, Fan Z-H, Li Y, Jia W-T, Guo Y-P. Graphene oxide-modified layered double hydroxide/chitosan nacre-mimetic scaffolds treat breast cancer metastasis-induced bone defects. Carbon. 2022;200:63–74.
Zhu Z, Li C, Lin Y, Li L, Liu K, Wen W, et al. Versatile 3D printing scaffold with Spatiotemporal release of multiple drugs for bone regeneration. ACS Nano. 2025;19:13637–53.
baradaran T, Shafiei SS, Mohammadi S, Moztarzadeh F. Poly (ε-caprolactone)/layered double hydroxide microspheres-aggregated nanocomposite scaffold for osteogenic differentiation of mesenchymal stem cell. Mater Today Commun. 2020;23:100913.
Belgheisi G, Nazarpak MH, Hashjin MS. Bone tissue engineering electrospun scaffolds based on layered double hydroxides with the ability to release vitamin D3: fabrication, characterization and in vitro study. Appl Clay Sci. 2020;185:105434.
Alarçin E, İzbudak B, Yüce Erarslan E, Domingo S, Tutar R, Titi K, et al. Optimization of methacrylated gelatin /layered double hydroxides nanocomposite cell-laden hydrogel Bioinks with high printability for 3D extrusion Bioprinting. J Biomed Mater Res A. 2023;111:209–23.
Fayyazbakhsh F, Solati-Hashjin M, Keshtkar A, Shokrgozar MA, Dehghan MM, Larijani B. Novel layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffolds: fabrication, characterization, and in vivo study. Mater Sci Eng: C. 2017;76:701–14.
Fayyazbakhsh F, Solati-Hashjin M, Keshtkar A, Shokrgozar MA, Dehghan MM, Larijani B. Release behavior and signaling effect of vitamin D3 in layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffold: an in vitro evaluation. Colloids Surf B: Biointerfaces. 2017;158:697–708.
Wang S, Zhang Z, Dong L, Waterhouse GIN, Zhang Q, Li L. A remarkable thermosensitive hydrogel cross-linked by two inorganic nanoparticles with opposite charges. J Colloid Interface Sci. 2019;538:530–40.
Sun W, Ye B, Chen S, Zeng L, Lu H, Wan Y, et al. Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges. Bone Res. 2023;11:1–26.
Zhang H, Zhang M, Zhai D, Qin C, Wang Y, Ma J, et al. Polyhedron-Like biomaterials for innervated and vascularized bone regeneration. Adv Mater. 2023;35:2302716.
Bai Y, Wang Z, Yu L, Dong K, Cheng L, Zhu R. The enhanced generation of motor neurons from mESCs by MgAl layered double hydroxide nanoparticles. Biomed Mater. 2023;18:034101.
Bai Y, Zhu Y, He X, Huang R, Xu X, Yang L et al. Size-Optimized layered double hydroxide nanoparticles promote neural progenitor cells differentiation of embryonic stem cells through the regulation of M6A methylation. Int J Nanomed 2024:4181–97.
Zhu R, Zhu X, Zhu Y, Wang Z, He X, Wu Z, et al. Immunomodulatory layered double hydroxide nanoparticles enable neurogenesis by targeting transforming growth Factor-β receptor 2. ACS Nano. 2021;15:2812–30.
Mondal S, Park S, Choi J, Vu TTH, Doan VHM, Vo TT, et al. Hydroxyapatite: A journey from biomaterials to advanced functional materials. Adv Colloid Interface Sci. 2023;321:103013.
Kasi PB, Serafin A, O’Brien L, Moghbel N, Novikov LN, Kelk P, et al. Electroconductive gelatin/hyaluronic acid/hydroxyapatite scaffolds for enhanced cell proliferation and osteogenic differentiation in bone tissue engineering. Biomater Adv. 2025;173:214286.
Beheshtizadeh N, Seraji AA, Azadpour B, Rezvantalab S. The stability and self-assembly of tri-calcium silicate and hydroxyapatite scaffolds in bone tissue engineering applications. J Biol Eng. 2025;19:16.
Peng Y, Lan L, Mu J, Hou S, Cheng L. [Research progress on biocomposites based on bioactive glass]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = J Biomed Eng = Shengwu Yixue Gongchengxue Zazhi. 2023;40:805–11.
Zhu Y, Zhang X, Chang G, Deng S, Chan HF. Bioactive glass in tissue regeneration: unveiling recent advances in regenerative strategies and applications. Adv Mater (Deerf Beach Fla). 2025;37:e2312964.
Garimella A, Ghosh SB, Bandyopadhyay-Ghosh S. Biomaterials for bone tissue engineering: achievements to date and future directions. Biomed Mater (Bristol Engl). 2024;20:012001.
Bezerra Melo MC, Spirandeli BR, Barbosa L, Ribeiro Dos Santos V, Bastos de Campos TM, Thim GP, et al. Enhanced mechanical strength and bioactivity of 3D-printed β-TCP scaffolds coated with bioactive glasses. J Mech Behav Biomed Mater. 2025;163:106850.
Yu F, Zhao X, Zhang S, Lu W, Li P, Yang W, et al. Regulation of T cell glycosylation by MXene/β-TCP nanocomposite for enhanced mandibular bone regeneration. Adv Healthc Mater. 2025;14:e2404015.
Song Y, Wang H, Liu Q, Li G, Wang S, Zhu X. Sodium Dodecyl sulfate (SDS) intercalated MgAl layered double hydroxides film to enhance the corrosion resistance of AZ31 magnesium alloy. Surf Coat Technol. 2021;422:127524.
Wang Y, Zhou X, Yin M, Pu J, Yuan N, Ding J. Superhydrophobic and Self-Healing Mg-Al layered double hydroxide/silane composite coatings on the Mg alloy surface with a Long-Term Anti-corrosion lifetime. Langmuir. 2021;37:8129–38.
Wu W, Sun X, Zhu C-L, Zhang F, Zeng R-C, Zou Y-H, et al. Biocorrosion resistance and biocompatibility of Mg–Al layered double hydroxide/poly-L-glutamic acid hybrid coating on magnesium alloy AZ31. Prog Org Coat. 2020;147:105746.
Kaseem M, Ramachandraiah K, Hossain S, Dikici B. A review on LDH-Smart functionalization of anodic films of Mg alloys. Nanomater (Basel Switz). 2021;11:536.
Li Q, Wang D, Qiu J, Peng F, Liu X. Regulating the local pH level of titanium via Mg–Fe layered double hydroxides films for enhanced osteogenesis. Biomater Sci. 2018;6:1227–37.
Zhou W, Zhang W, Chen Z. Universal biomimetic Preparation and immobilization of layered double hydroxide films and adsorption behavior. Appl Surf Sci. 2017;392:153–61.
Saghati S, Nasrabadi HT, Khoshfetrat AB, Moharamzadeh K, Hassani A, Mohammadi SM, et al. Tissue engineering strategies to increase osteochondral regeneration of stem cells; a close look at different modalities. Stem Cell Rev Rep. 2021;17:1294–311.
Aliakbarzadeh S, Abdouss M, Ali Khonakdar H, Rahdar A, Fathi-karkan S. Gelatin methacrylate/poly(2-ethyl-2-oxazoline) porous hydrogel loaded with Kartogenin drug as a biocompatible scaffold for cartilage tissue regeneration. J Mol Liq. 2024;404:124982.
Dalmonte T, Andreani G, Rudelli C, Isani G. Efficacy of extracts of Oleogum resin of Boswellia in the treatment of knee osteoarthritis: A systematic review and Meta-Analysis. Phytother Res: PTR. 2024;38:5672–89.
Cometa S, Busto F, Scalia AC, Castellaneta A, Gentile P, Cochis A, et al. Effectiveness of Gellan gum scaffolds loaded with Boswellia serrata extract for in-situ modulation of pro-inflammatory pathways affecting cartilage healing. Int J Biol Macromol. 2024;277:134079.
Trucco D, Riacci L, Vannozzi L, Manferdini C, Arrico L, Gabusi E, et al. Primers for the adhesion of Gellan Gum-Based hydrogels to the cartilage: A comparative study. Macromol Biosci. 2022;22:e2200096.
Zhang H, Yan W, Wang J, Xie S, Tao WA, Lee C-W, et al. Surface functionalization of exosomes for chondrocyte-targeted SiRNA delivery and cartilage regeneration. J Control Release. 2024;369:493–505.
Su C, Lin D, Huang X, Feng J, Jin A, Wang F, et al. Developing hydrogels for gene therapy and tissue engineering. J Nanobiotechnol. 2024;22:182.
Lee SS, Choi GE, Lee HJ, Kim Y, Choy J-H, Jeong B. Layered double hydroxide and polypeptide thermogel nanocomposite system for chondrogenic differentiation of stem cells. ACS Appl Mater Interfaces. 2017;9:42668–75.
Liu P, Li M, Yu H, Fang H, Yin J, Zhu D, et al. Biphasic CK2.1-coated β-glycerophosphate Chitosan/LL37-modified layered double hydroxide Chitosan composite scaffolds enhance coordinated hyaline cartilage and subchondral bone regeneration. Chem Eng J. 2021;418:129531.
Gao J, Feng L, Chen B, Fu B, Zhu M. The role of rare Earth elements in bone tissue engineering scaffolds – A review. Compos B: Eng. 2022;235:109758.
Gao X, Zhang J, Gong Y, Yan L. The biomedical applications of nanozymes in orthopaedics based on regulating reactive oxygen species. J Nanobiotechnol. 2024;22:569.
Xie M, Pan B, Li N, Zhao S, Yan J, Guo S, et al. 2D Graphene/FeOCl heterojunctions with enhanced tribology performance as a lubricant additive for liquid paraffin. RSC Adv. 2022;12:2759–69.
Kałużny J, Świetlicka A, Wojciechowski Ł, Boncel S, Kinal G, Runka T, et al. Machine learning approach for Application-Tailored nanolubricants’ design. Nanomater (Basel Switz). 2022;12:1765.
Zhao N, Pessell AF, Zhu N, Searson PC. Tissue-Engineered microvessels: A review of current engineering strategies and applications. Adv Healthc Mater. 2024;13:e2303419.
Cheng S, Lan L, Li M, Chu X, Zhong H, Yao M, et al. Pure Mg–Al layered double hydroxide film on magnesium alloys for orthopedic applications. ACS Omega. 2021;6:24575–84.
Sun X, Zhang Y, Li J, Park KS, Han K, Zhou X, et al. Amplifying STING activation by Cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy. Nat Nanotechnol. 2021;16:1260–70.
Duan J, Chen Z, Liang X, Chen Y, Li H, Tian X, et al. Construction and application of therapeutic metal-polyphenol capsule for peripheral artery disease. Biomaterials. 2020;255:120199.
Kang Y, Xu C, Meng L, Dong X, Qi M, Jiang D. Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration. Bioact Mater. 2022;18:26–41.
Chen X, He S, Dong Y, Chen M, Xia Z, Cai K, et al. Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing. Mater Today Bio. 2024;24:100912.
Lai Y, Gao FF, Ge RT, Liu R, Ma S, Liu X. Metal ions overloading and cell death. Cell Biol Toxicol. 2024;40:72.
Yoshida YG, Yan S, Xu H, Yang J. Novel metal nanomaterials to promote angiogenesis in tissue regeneration. Eng Regen. 2023;4:265–76.
Liu Y, Gong X, Wang J, Wang Y, Zhang Y, Li T, et al. Investigation of nickel sulfate-induced cytotoxicity and underlying toxicological mechanisms in human umbilical vein endothelial cells through oxidative stress, inflammation, apoptosis, and MAPK signaling pathways. Environ Toxicol. 2022;37:2058–71.
Oliveira-Paula GH, Martins AC, Ferrer B, Tinkov AA, Skalny AV, Aschner M. The impact of manganese on vascular endothelium. Toxicol Res. 2024;40:501–17.
Phan VHG, Duong H-S, Le Q-GT, Janarthanan G, Vijayavenkataraman S, Nguyen H-NH, et al. Nanoengineered injectable hydrogels derived from layered double hydroxides and alginate for sustained release of protein therapeutics in tissue engineering applications. J Nanobiotechnol. 2023;21:405.
Luo Z, Yao J, Wang Z, Xu J. Mitochondria in endothelial cells angiogenesis and function: current Understanding and future perspectives. J Transl Med. 2023;21:441.
Hasan SS, Jabs M, Taylor J, Wiedmann L, Leibing T, Nordström V, et al. Endothelial Notch signaling controls insulin transport in muscle. EMBO Mol Med. 2020;12:e09271.
Zhai Q, Chen X, Fei D, Guo X, He X, Zhao W, et al. Nanorepairers rescue Inflammation-Induced mitochondrial dysfunction in mesenchymal stem cells. Adv Sci (Weinh Baden-Wurtt Ger). 2022;9:e2103839.
Hunt M, Torres M, Bachar-Wikstrom E, Wikstrom JD. Cellular and molecular roles of reactive oxygen species in wound healing. Commun Biol. 2024;7:1534.
Gong W, Das S, Sierra-Pagan JE, Skie E, Dsouza N, Larson TA, et al. ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage. Nat Cell Biol. 2022;24:672–84.
Du H, Li B, Yu R, Lu X, Li C, Zhang H, et al. ETV2 regulating PHD2-HIF-1α axis controls metabolism reprogramming promotes vascularized bone regeneration. Bioact Mater. 2024;37:222–38.
Liu X, Hu T, Lin G, Wang X, Zhu Y, Liang R, et al. The synthesis of a DHAD/ZnAlTi-LDH composite with advanced UV blocking and antibacterial activity for skin protection. RSC Adv. 2020;10:9786–90.
Sorg H, Sorg CGG. Skin wound healing: of players, patterns, and processes. Eur Surg Res. 2023;64:141–57.
Fernandes JDC, Pinto C, Kang TS, De Magalhães Padilha HR, Koh P, Constantino IHJ. Layered double hydroxides are promising nanomaterials for tissue bioengineering application. Adv Biosyst. 2019;3:1800238.
Cabral-Pacheco GA, Garza-Veloz I, Castruita-De La Rosa C, Ramirez-Acuña JM, Perez-Romero BA, Guerrero-Rodriguez JF, et al. The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci. 2020;21:9739.
Gardeazabal L, Izeta A. Elastin and collagen fibres in cutaneous wound healing. Exp Dermatol. 2024;33:e15052.
Mohammadi A, Abdolvand H, Ayati Najafabadi SA, Nejaddehbashi F, Beigi-Boroujeni S, Makvandi P, et al. Antibacterial Host–Guest intercalated LDH-Adorned polyurethane for accelerated dermal wound healing. ACS Appl Bio Mater. 2022;5:5800–15.
Shiny PJ, Vimala Devi M, Felciya SJG, Ramanathan G, Fardim P, Sivagnanam UT. In vitro and in vivo evaluation of poly-3-hydroxybutyric acid-sodium alginate as a core-shell nanofibrous matrix with arginine and bacitracin-nanoclay complex for dermal reconstruction of excision wound. Int J Biol Macromol 2021;168:46–58.
Zhang W, Zhang B, Wang Y, Cao X, Wang J, Lu W, et al. Gelatin-Based hydrogel functionalized with dopamine and layered double hydroxide for wound healing. Gels. 2024;10:318.
Szerlauth A, Madácsy T, Samu GF, Bíró P, Erdélyi M, Varga G, et al. Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide. Chem Commun. 2024;60:1325–8.
Xue Y, Zhang Y, Zhong Y, Du S, Hou X, Li W, et al. LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing. Nat Commun. 2024;15:1–13.
Awassa J, Cornu D, Soulé S, Carteret C, Ruby C, El-Kirat-Chatel S. Divalent metal release and antimicrobial effects of layered double hydroxides. Appl Clay Sci. 2022;216:106369.
Yoosefi S, Rakhshani A, Montazeri V, Tavakoli M, Aliabadi A, Fatahi Y, et al. Dual drug delivery system based on layered double hydroxides/carboxymethyl cellulose-poly ethylene oxide Bionanocomposite electrospun fibrous Mats: fabrication, characterization, in-vitro and in-vivo studies. Int J Biol Macromol. 2022;222:3142–54.
Li X, Gong P, Li Y, Yu J, Wang F, Li X, et al. Double-carrier drug delivery system based on polyurethane-polyvinyl alcohol/layered double hydroxide nanocomposite hydrogel. Mater Lett. 2019;243:1–4.
Malafatti JOD, Bernardo MP, Moreira FKV, Ciol H, Inada NM, Mattoso LHC, et al. Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]-layered double hydroxide as an antimicrobial wound dressing. Polym Adv Technol. 2020;31:1377–87.
Stoica AE, Chircov C, Grumezescu AM. Nanomaterials for wound dressings: an Up-to-Date overview. Mol (Basel Switz). 2020;25:2699.
Du S, Zhou N, Xie G, Chen Y, Suo H, Xu J, et al. Surface-engineered triboelectric nanogenerator patches with drug loading and electrical stimulation capabilities: toward promoting infected wounds healing. Nano Energy. 2021;85:106004.
Liu Y, Sun Y, Li S, Liu M, Qin X, Chen X, et al. Tetrahedral framework nucleic acids deliver antimicrobial peptides with improved effects and less susceptibility to bacterial degradation. Nano Lett. 2020;20:3602–10.
Asghari Niari S, Rahbarghazi R, Salehi R, Kazemi L, Fathi Karkan S, Karimipour M. Fabrication, characterization and evaluation of the effect of PLGA and PLGA–PEG biomaterials on the proliferation and neurogenesis potential of human neural SH-SY5Y cells. Microsc Res Tech. 2022;85:1433–43.
Pang X, Zhang T, Li J, Yu L, Liu Z, Liu Y, et al. LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway. Biomaterials. 2025;314:122873.
Hu X, Xu W, Ren Y, Wang Z, He X, Huang R, et al. Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2023;8:245.
Xu X, Song L, Li Y, Guo J, Huang S, Du S, et al. Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway. J Transl Med. 2023;21:1–20.
Wang L, Zhang B, Yang X, Guo S, Waterhouse GIN, Song G, et al. Targeted alleviation of ischemic stroke reperfusion via atorvastatin-ferritin Gd-layered double hydroxide. Bioact Mater. 2023;20:126–36.
Zhang T, Wang Z, Wang Z, Pang X, Yang L, Li L, et al. LDH-doped gelatin-chitosan scaffold with aligned microchannels improves anti-inflammation and neuronal regeneration with guided axonal growth for effectively recovering spinal cord injury. Appl Mater Today. 2023;34:101884.
Zha S, Liu H, Li H, Li H, Wong K-L, All AH. Functionalized nanomaterials capable of crossing the Blood-Brain barrier. ACS Nano. 2024;18:1820–45.
Cogill SA, Lee J-H, Jeon M-T, Kim D-G, Chang Y. Hopping the hurdle: strategies to enhance the molecular delivery to the brain through the Blood-Brain barrier. Cells. 2024;13:789.
Cheng G, Liu Y, Ma R, Cheng G, Guan Y, Chen X, et al. Anti-Parkinsonian therapy: strategies for crossing the Blood-Brain barrier and Nano-Biological effects of nanomaterials. Nano-Micro Lett. 2022;14:105.
Villanueva MT. Engineered nasal bacteria slide drugs into the brain. Nat Rev Drug Discov. 2025;24:247.
Samaridou E, Walgrave H, Salta E, Álvarez DM, Castro-López V, Loza M, et al. Nose-to-brain delivery of enveloped RNA – cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases. Biomaterials. 2020;230:119657.
Chia S, Cataldi RL, Ruggeri FS, Limbocker R, Condado-Morales I, Pisani K, et al. A relationship between the structures and neurotoxic effects of Aβ oligomers stabilized by different metal ions. ACS Chem Neurosci. 2024;15:1125–34.
Kim H, Harrison FE, Aschner M, Bowman AB. Exposing the role of metals in neurological disorders: a focus on manganese. Trends Mol Med. 2022;28:555–68.
Yoo J, Han J, Hee Lim M. Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration. RSC Chem Biol. 2023;4:548–63.
Kulkarni D, Musale S, Panzade P, Paiva-Santos AC, Sonwane P, Madibone M, et al. Surface functionalization of nanofibers: the multifaceted approach for advanced biomedical applications. Nanomaterials. 2022;12:3899.
Kulkarni D, Giram P, Mahore J, Kapare H, Panzade P. Electrospun nanofibers: a promising paradigm for biomedical applications. Int J Polym Mater Polym Biomaterials. 2025;74:403–23.
Garkal A, Kulkarni D, Musale S, Mehta T, Giram P. Electrospinning nanofiber technology: a multifaceted paradigm in biomedical applications. New J Chem. 2021;45:21508–33.
Creeth J, Smith G, Franks B, Hara A, Zero D. Remineralisation of enamel erosive lesions by daily-use fluoride treatments: network meta-analysis of an in situ study set. Clin Oral Investig. 2024;29:28.
Hoxha A, Karpukhina N, Gillam DG, Bushby AJ, Patel MP. Fluoride rechargeable layered double hydroxide powders for dental applications. Appl Clay Sci. 2021;200:105863.
Hoxha A, Gillam DG, Agha A, Karpukhina N, Bushby AJ, Patel MP. Novel fluoride rechargeable dental composites containing MgAl and CaAl layered double hydroxide (LDH). Dent Mater. 2020;36:973–86.
Luo D, Liu X, Dai S, Yi J, Tang N, Cai Y, et al. Highly crystalline copper Aluminum-Layered double hydroxides with intrinsic Fenton-Like catalytic activity for robust oral health management. Inorg Chem. 2024;63:10691–704.
Yin Y, Jian L, Li B, Liang C, Han X, Zhao X, et al. Mg-Fe layered double hydroxides modified titanium enhanced the adhesion of human gingival fibroblasts through regulation of local pH level. Mater Sci Eng: C. 2021;131:112485.
Ghiasi M, Hashemi M, Salimi A, Jadidi K, Tavallaie M, Aghamollaei H. Combination of natural scaffolds and conditional medium to induce the differentiation of adipose-derived mesenchymal stem cells into keratocyte-like cells and its safety evaluation in the animal cornea. Tissue Cell. 2023;82:102117.
Uzel E, Durgun ME, Esentürk-Güzel İ, Güngör S, Özsoy Y. Nanofibers in ocular drug targeting and tissue engineering: their importance, advantages, advances, and future perspectives. Pharmaceutics. 2023;15:1062.
Novack GD, Robin AL. Ocular Pharmacology. J Clin Pharmacol. 2024;64:1068–82.
Xu C, Lu J, Zhou L, Liang J, Fang L, Cao F. Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye. Carbohydr Polym. 2021;260:117800.
Sun J, Lei Y, Dai Z, Liu X, Huang T, Wu J, et al. Sustained release of brimonidine from a new composite drug delivery system for treatment of Glaucoma. ACS Appl Mater Interfaces. 2017;9:7990–9.
Sowmya B, Hemavathi AB, Panda PK. Poly (ε-caprolactone)-based electrospun nano-featured substrate for tissue engineering applications: a review. Prog Biomater. 2021;10:91–117.
Selvaraj S, Chauhan A, Radhakrishnan A, Rana G, Dutta V, Batoo KM, et al. Cerium oxide nanoparticles and their polymeric composites: advancements in biomedical applications. J Inorg Organomet Polym Mater. 2024;34:5691–717.
Strimaite M, Wells CJ R, Prior J, Stuckey TJ, Wells DA, Davies J. Layered rare-earth hydroxides as multi-modal medical imaging probes: particle size optimisation and compositional exploration. Dalton Trans. 2024;53:8429–42.
Selvaraj S, Chauhan A, Dutta V, Verma R, Rao SK, Radhakrishnan A, et al. A state-of-the-art review on plant-derived cellulose-based green hydrogels and their multifunctional role in advanced biomedical applications. Int J Biol Macromol. 2024;265:130991.
Selvaraj S, Chauhan A, Verma R, Dutta V, Rana G, Duglet R, et al. Role of degrading hydrogels in hepatocellular carcinoma drug delivery applications: A review. J Drug Deliv Sci Technol. 2024;95:105628.
Shen W, Hu T, Liu X, Zha J, Meng F, Wu Z, et al. Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy. Nat Commun. 2022;13:3384.
Zhu Y, Wang Y, Williams GR, Fu L, Wu J, Wang H et al. Multicomponent Transition Metal Dichalcogenide Nanosheets for Imaging-Guided Photothermal and Chemodynamic Therapy. Adv, Sci, 2020;7:2000272.
Cao Z, Zhang L, Liang K, Cheong S, Boyer C, Gooding JJ, et al. Biodegradable 2D Fe–Al hydroxide for nanocatalytic tumor-Dynamic therapy with tumor specificity. Adv Sci. 2018;5:1801155.
Pagar RR, Musale SR, Pawar G, Kulkarni D, Giram PS. Comprehensive review on the degradation chemistry and toxicity studies of functional materials. ACS Biomater Sci Eng. 2022;8:2161–95.
Chen M, Cai Y, Zhang M, Yu L, Wu F, Jiang J, et al. Novel Ca-SLS-LDH nanocomposites obtained via lignosulfonate modification for corrosion protection of steel bars in simulated concrete pore solution. Appl Clay Sci. 2021;211:106195.
Pang H, Wu Y, Chen Y, Chen C, Nie X, Li P, et al. Development of polysaccharide-coated layered double hydroxide nanocomposites for enhanced oral insulin delivery. Drug Deliv Transl Res. 2024;14:2345–55.
Chen C, Buffet J-C, O’Hare D. Surface modification of aqueous miscible organic layered double hydroxides (AMO-LDHs). Dalton Trans. 2020;49:8498–503.
Khalili L, Dehghan G, Akbar Moosavi-Movahedi A, Yoon Y, Khataee A. In vitro and in Silico insights into the molecular interaction mechanism of acetylshikonin with bovine serum albumin. J Mol Liq. 2022;365:120191.
Li J, Li B, Sun J, Ma C, Wan S, Li Y, et al. Engineered Near-Infrared fluorescent protein assemblies for robust bioimaging and therapeutic applications. Adv Mater. 2020;32:2000964.
Zhang Q, Liang J, Bongers A, Richardson JJ, Liang K, Gu Z. Site-Specific antibody assembly on nanoparticles via a versatile coating method for improved cell targeting. Adv Sci. 2023;10:2206546.
Xu H, Liu Y, Wang K, Jin L, Chen J, Chen H, et al. High-entropy layered double hydroxides tailor Pt electron state for promoting acidic hydrogen evolution reaction. J Colloid Interface Sci. 2025;684:566–74.
Maslah H, Skarbek C, Gourson C, Plamont M-A, Pethe S, Jullien L, et al. In-Cell generation of anticancer phenanthridine through bioorthogonal cyclization in antitumor prodrug development. Angew Chem Int Ed. 2021;60:24043–7.
Rezaei H, Shahrezaee M, Monfared MJ, Karkan SF, Ghafelehbashi R. Simvastatin-loaded graphene oxide embedded in polycaprolactone-polyurethane nanofibers for bone tissue engineering applications. J Polym Eng. 2021;41:375–86.
Saghati S, Rahbarghazi R, Fathi Karkan S, Nazifkerdar S, Khoshfetrat AB, Tayefi Nasrabadi H. Shape memory polymers in osteochondral tissue engineering. J Res Clin Med. 2022;10:30.
McIntyre CW, Pai P, Warwick G, Wilkie M, Toft AJ, Hutchison AJ. Iron-Magnesium hydroxycarbonate (Fermagate): A novel Non-Calcium-Containing phosphate binder for the treatment of hyperphosphatemia in chronic Hemodialysis patients. Clin J Am Soc Nephrol. 2009;4:401.
Zhu R, Cheng L. Application of nano layered double hydroxide in cartilage regeneration and Preparation thereof. US2024416002 (A1), 2024.
Hine CE, Franks MA, Patel M, Karpukhina N, Hill R, Parker S. Dental Composition. US20190099337A1, 2019.